Full Product Name
INHA Antibody
Product Synonym Names
INHA
Product Gene Name
anti-INHA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05111
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human INHA expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C.
Other Notes
Small volumes of anti-INHA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-INHA antibody
Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a, b, c, d).
Product Categories/Family for anti-INHA antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-INHA antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-INHA antibody
WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:10000
Western Blot (WB) of anti-INHA antibody
Figure 1: Western blot analysis using INHA mouse mAb against mouse spermary (1) tissues lysate.
Immunofluorescence (IF) of anti-INHA antibody
Figure 2: Immunofluorescence analysis of PANC-1 cells using INHA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
NCBI/Uniprot data below describe general gene information for INHA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002182.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002191.3
[Other Products]
UniProt Primary Accession #
P05111
[Other Products]
UniProt Secondary Accession #
A8K8H5[Other Products]
UniProt Related Accession #
P05111[Other Products]
NCBI Official Full Name
inhibin alpha chain preproprotein
NCBI Official Synonym Full Names
inhibin subunit alpha
NCBI Official Symbol
INHA [Similar Products]
NCBI Protein Information
inhibin alpha chain
UniProt Protein Name
Inhibin alpha chain
UniProt Gene Name
INHA [Similar Products]
NCBI Summary for INHA
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
UniProt Comments for INHA
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Research Articles on INHA
1. HIF1A and EPAS1 potentiate hypoxia-induced upregulation of INHA expression in human term cytotrophoblasts in vitro.
Precautions
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Disclaimer
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