G protein-activated inward rectifier potassium channel 4, KCNJ5/GIRK4, ELISA Ki

For Research Use Only. Not for use in diagnostic procedures.

Store at 2 to 8 degree C for 6 months.

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Small volumes of KCNJ5/GIRK4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1600965 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the G protein-activated inward rectifier potassium channel 4, KCNJ5/GIRK4, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNJ5/GIRK4. The ELISA analytical biochemical technique of the MBS1600965 kit is based on KCNJ5/GIRK4 antibody-KCNJ5/GIRK4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNJ5/GIRK4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNJ5/GIRK4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

47,668 Da

potassium voltage-gated channel subfamily J member 5

G protein-activated inward rectifier potassium channel 4

G protein-activated inward rectifier potassium channel 4

GIRK4; GIRK-4; CIR; IRK-4  [Similar Products]

This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

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