CLEC4C/BDCA2, Polyclonal Antibody

CLEC4C; C-type lectin domain family 4, member C; BDCA2; CD303; CLECSF11; CLECSF7; DLEC; HECL; MGC125789; MGC125791; MGC125792; MGC125793; PRO34150; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11; C-type (calcium; CLEC4C antibody; C-type lectin domain family 4; member C antibody; BDCA2 antibody; CD303 antibody; CLECSF11 antibody; CLECSF7 antibody; DLEC antibody; HECL antibody; MGC125789 antibody; MGC125791 antibody; MGC125792 antibody; MGC125793 antibody; PRO34150 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 11 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 7 antibody; C-type lectin domain family 4; member C; isoform 1 antibody; blood dendritic cell antigen 2 protein antibody; dendritic cell lectin b antibody; CLEC4C / BDCA2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-CLEC4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 20kDa band observed in Human Spleen lysates (calculated MW of 21.5kDa according to NP_987099.1). Recommended concentration: 1-3ug/ml.

(1ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

21,498 Da

C-type lectin domain family 4 member C

C-type lectin domain family 4 member C

C-type lectin domain family 4 member C

BDCA2; CLECSF11; CLECSF7; DLEC; HECL; BDCA-2  [Similar Products]

CLC4C_HUMAN

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC4C: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: carbohydrate binding

Biological Process: adaptive immune response; innate immune response; stimulatory C-type lectin receptor signaling pathway

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