PDCD6, cDNA Clone

For Research Use Only. Not for use in diagnostic procedures.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of PDCD6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

7,349 Da

programmed cell death 6

programmed cell death protein 6

Programmed cell death protein 6

ALG2  [Similar Products]

PDCD6_HUMAN

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; nucleus

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity

Biological Process: intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; response to calcium ion

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