Product Name
Mesothelin (MSLN), CLIA Kit
Full Product Name
Mesothelin (Human) LumiAb ELISA Kit
Product Synonym Names
Human Mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; MPF
Product Gene Name
MSLN clia kit
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sample Manual Insert
Download Sample PDF Manual View Sample PDF Manual
Request for Current Manual Insert
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3D Structure
ModBase 3D Structure for Q13421
Specificity
The LumiAb, Human Mesothelin ELISA is capable of recognizing both recombinant and naturally produced Human Mesothelin proteins.
The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.
Human: Mesothelin Propeptide (aa 35-289), MUC-1, MUC 16
Assay Type
Sandwich ELISA
Detection Range
31-2000 pg/ml
Detection Method
Luminometer
Preparation and Storage
Store at 4 degree C for 6 months.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of MSLN clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for MSLN clia kit
Luminometer Sandwich ELISA
NCBI/Uniprot data below describe general gene information for MSLN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005814.2
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NCBI GenBank Nucleotide #
NM_005823.6
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UniProt Primary Accession #
Q13421
[Other Products]
UniProt Related Accession #
Q13421[Other Products]
NCBI Official Full Name
mesothelin isoform 1 preproprotein
NCBI Official Synonym Full Names
mesothelin
NCBI Official Symbol
MSLN [Similar Products]
NCBI Official Synonym Symbols
MPF; SMRP
[Similar Products]
NCBI Protein Information
mesothelin
UniProt Protein Name
Mesothelin
UniProt Synonym Protein Names
CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
Protein Family
Mesothelin
UniProt Gene Name
MSLN [Similar Products]
UniProt Synonym Gene Names
MPF; MPF [Similar Products]
UniProt Entry Name
MSLN_HUMAN
NCBI Summary for MSLN
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Comments for MSLN
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Cell adhesion
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane
Molecular Function: protein binding
Biological Process: pancreas development; cell adhesion
Research Articles on MSLN
1. Results found that MESO protein was highly expressed in the cervical squamous cell carcinoma. When MSLN was knocked down in SiHa cells, cell apoptosis increased, but no significant effects were observed on cell proliferation and migration. Thus, the study shows that MSLN plays a role in the apoptosis of cervical squamous cell carcinoma cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
