NKX3-2 / BAPX1, Polyclonal Antibody

Anti-NKX3-2 / BAPX1 Antibody (Internal) IHC-plus; NKX3-2; NK3 homeobox 2; NKX3.2; Homeobox protein Nkx-3.2; BAPX1; NKX3B; SMMD; Human NKX3-2; BAPX1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human NKX3-2 / BAPX1. BAPX1 antibody is predicted not to cross-react with other NKX homeobox proteins.

Immunoaffinity Purified

PBS, 0.02% sodium azide

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Small volumes of anti-NKX3-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)

Anti-NKX3-2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence of BAPX1 in mouse brain tissue with BAPX1 antibody at 20 ug/ml.

Western blot analysis of BAPX1 in human brain tissue lysate with BAPX1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

34,814 Da

NK3 homeobox 2

homeobox protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1

Homeobox protein Nkx-3.2

BAPX1; NKX3B  [Similar Products]

NKX32_HUMAN

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.

Protein type: Cell development/differentiation; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleus

Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; pancreas development; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; determination of left/right symmetry; skeletal development; negative regulation of apoptosis

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

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