Product Name
FERRITIN (FTL), Polyclonal Antibody
Full Product Name
SHEEP ANTI HUMAN FERRITIN
Product Gene Name
anti-FTL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Specificity
Reacts with human ferritin.
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Native human ferritin from liver.
Buffer Solution
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-FTL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FTL antibody
Reacts with human ferritin.
Applications Tested/Suitable for anti-FTL antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000137.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000146.3
[Other Products]
UniProt Secondary Accession #
Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9[Other Products]
UniProt Related Accession #
P02792[Other Products]
Molecular Weight
20,020 Da[Similar Products]
NCBI Official Full Name
ferritin light chain
NCBI Official Synonym Full Names
ferritin, light polypeptide
NCBI Official Symbol
FTL [Similar Products]
NCBI Official Synonym Symbols
LFTD; NBIA3
[Similar Products]
NCBI Protein Information
ferritin light chain; ferritin L subunit; ferritin L-chain; ferritin light polypeptide-like 3
UniProt Protein Name
Ferritin light chain
UniProt Gene Name
FTL [Similar Products]
UniProt Synonym Gene Names
Ferritin L subunit [Similar Products]
UniProt Entry Name
FRIL_HUMAN
NCBI Summary for FTL
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for FTL
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as *****-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: ferritin complex; membrane; cytosol
Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding
Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; transmembrane transport; iron ion transport
Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
Research Articles on FTL
1. provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
