CCDC6, Polyclonal Antibody

Anti -CCDC6 (D10S170, TST1, Coiled-coil Domain-containing Protein 6, Papillary Thyroid Carcinoma-encoded Protein, Protein H4, FLJ32286, H4, PTC, TPC)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (61548505..61666414, complement). Location: 10q21

Polyclonal

IgG

Rabbit

Recognizes human CCDC6.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CCDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

Antibodies; Abs to CCDC (Coiled-coil Domain-containing)

Western Blot (WB)

Suitable for use in Western Blot.

53,291 Da[Similar Products]

coiled-coil domain containing 6

coiled-coil domain-containing protein 6; papillary thyroid carcinoma-encoded protein

Coiled-coil domain-containing protein 6

D10S170; TST1  [Similar Products]

CCDC6_HUMAN

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Protein type: Oncoprotein; Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding

Disease: Thyroid Carcinoma, Papillary

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