Product Name
F11, cDNA Clone
Full Product Name
F11 cDNA Clone
Product Gene Name
F11 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGATTTTCT TATATCAAGT GGTACATTTC ATTTTATTTA CTTCAGTTTC TGGTGAATGT GTGACTCAGT TGTTGAAGGA CACCTGCTTT GAAGGAGGGG ACATTACTAC GGTCTTCACA CCAAGCGCCA AGTACTGCCA GGTAGTCTGC ACTTACCACC CAAGATGTTT ACTCTTCACT TTCACGGCGG AATCACCATC TGAGGATCCC ACCCGATGGT TTACTTGTGT CCTGAAAGAC AGTGTTACAG AAACACTGCC AAGAGTGAAT AGGACAGCAG CGATTTCTGG GTATTCTTTC AAGCAATGCT CACACCAAAT AAGCGCTTGC AACAAAGACA TTTATGTGGA CCTAGACATG AAGGGCATAA ACTATAACAG CTCAGTTGCC AAGAGTGCTC AAGAATGCCA AGAAAGATGC ACGGATGACG TCCACTGCCA CTTTTTCACG TACGCCACAA GGCAGTTTCC CAGCCTGGAG CATCGTAACA TTTGTCTACT GAAGCACACC CAAACAGGGA CACCAACCAG AATAACGAAG CTCGATAAAG TGGTGTCTGG ATTTTCACTG AAATCCTGTG CACTTTCTAA TCTGGCTTGT ATTAGGGACA TTTTCCCTAA TACGGTGTTT GCAGACAGCA ACATCGACAG TGTCATGGCT CCCGATGCTT TTGTCTGTGG CCGAATCTGC ACTCATCATC CCGGTTGCTT GTTTTTTACC TTCTTTTCCC AGGAATGGCC CAAAGAATCT CAAAGAAATC TTTGTCTCCT TAAAACATCT GAGAGTGGAT TGCCCAGTAC ACGCATTAAA AAGAGCAAAG CTCTTTCTGG TTTCAGTCTA CAAAGCTGCA GGCACAGCAT CCCAGTGTTC TGCCATTCTT CATTTTACCA TGACACTGAT TTCTTGGGAG AAGAACTGGA TATTGTTGCT GCAAAAAGTC ACGAGGCCTG CCAGAAACTG TGCACCAATG CCGTCCGCTG CCAGTTTTTT ACCTATACCC CAGCCCAAGC ATCCTGCAAC GAAGGGAAGG GCAAGTGTTA CTTAAAGCTT TCTTCAAACG GATCTCCAAC TAAAATACTT CACGGGAGAG GAGGCATCTC TGGATACACA TTAAGGTTGT GTAAAATGGA TAATGAGTGT ACCACCAAAA TCAAGCCCAG GATCGTTGGA GGAACTGCGT CTGTTCGTGG TGAGTGGCCG TGGCAGGTGA CCCTGCACAC AACCTCACCC ACTCAGAGAC ACCTGTGTGG AGGCTCCATC ATTGGAAACC AGTGGATATT AACAGCCGCT CACTGTTTCT ATGGGGTAGA GTCACCTAAG ATTTTGCGTG TCTACAGTGG CATTTTAAAT CAATCTGAAA TAAAAGAGGA CACATCTTTC TTTGGGGTTC AAGAAATAAT AATCCATGAT CAGTATAAAA TGGCAGAAAG CGGGTATGAT ATTGCCTTGT TGAAACTGGA AACCACAGTG AATTACACAG ATTCTCAACG ACCCATATGC CTGCCTTCCA AAGGAGATAG AAATGTAATA TACACTGATT GCTGGGTGAC TGGATGGGGG TACAGAAAAC TAAGAGACAA AATACAAAAT ACTCTCCAGA AAGCCAAGAT ACCCTTAGTG ACCAACGAAG AGTGCCAGAA GAGATACAGA GGACATAAAA TAACCCATAA GATGATCTGT GCCGGCTACA GGGAAGGAGG GAAGGACGCT TGCAAGGGAG ATTCGGGAGG CCCTCTGTCC TGCAAACACA ATGAGGTCTG GCATCTGGTA GGCATCACGA GCTGGGGCGA AGGCTGTGCT CAAAGGGAGC GGCCAGGTGT TTACACCAAC GTGGTCGAGT ACGTGGACTG GATTCTGGAG AAAACTCAAG CAGTGTGA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of F11 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for F11. It may not necessarily be applicable to this product.
NCBI Accession #
BC119014
[Other Products]
UniProt Secondary Accession #
Q4W5C2; Q9Y495; D3DP64[Other Products]
UniProt Related Accession #
P03951[Other Products]
Molecular Weight
63,840 Da
NCBI Official Full Name
Homo sapiens coagulation factor XI, mRNA
NCBI Official Synonym Full Names
coagulation factor XI
NCBI Official Symbol
F11 [Similar Products]
NCBI Official Synonym Symbols
FXI
[Similar Products]
NCBI Protein Information
coagulation factor XI
UniProt Protein Name
Coagulation factor XI
UniProt Synonym Protein Names
Plasma thromboplastin antecedent; PTA
Protein Family
Coagulation factor
UniProt Gene Name
F11 [Similar Products]
UniProt Synonym Gene Names
FXI; PTA [Similar Products]
UniProt Entry Name
FA11_HUMAN
NCBI Summary for F11
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
UniProt Comments for F11
F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.27; Protease
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: extracellular region; extracellular space; plasma membrane
Molecular Function: protein binding
Biological Process: blood coagulation, intrinsic pathway; plasminogen activation; positive regulation of fibrinolysis
Disease: Factor Xi Deficiency
Research Articles on F11
1. Factor XI and factor XII activities were significantly higher in patients with slow coronary flow than in controls, and could be associated with enhanced procoagulant state present in these patients.
Precautions
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Disclaimer
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