Product Name
CD41 (ITGA2B), Monoclonal Antibody
Full Product Name
Anti-CD41 Antibody-PE labled
Product Synonym Names
GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD antigen CD41)
Product Gene Name
anti-ITGA2B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08514
Specificity
Recognises human CD41.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.
Preparation and Storage
Shipped and store at 4 degree C for one year. Do not freeze.
Other Notes
Small volumes of anti-ITGA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA2B antibody
Mouse monoclonal antibody to CD41 (PE)
Applications Tested/Suitable for anti-ITGA2B antibody
Immunofluoresence (IF), Flow Cytometry (FC/FACS)
Flow Cytometry (FC/FACS) of anti-ITGA2B antibody
Flow cytometric analysis of human platelet using Anti-CD41 Antibody-PE labled.
NCBI/Uniprot data below describe general gene information for ITGA2B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000410.2
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NCBI GenBank Nucleotide #
NM_000419.3
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UniProt Primary Accession #
P08514
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UniProt Secondary Accession #
O95366; Q14443; Q17R67; B2RCY8[Other Products]
UniProt Related Accession #
P08514[Other Products]
Molecular Weight
103,218 Da
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Official Symbol
ITGA2B [Similar Products]
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
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NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb
UniProt Gene Name
ITGA2B [Similar Products]
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb [Similar Products]
UniProt Entry Name
ITA2B_HUMAN
NCBI Summary for ITGA2B
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGA2B
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: platelet alpha granule membrane; focal adhesion; cell surface; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding
Biological Process: integrin-mediated signaling pathway; axon guidance; platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; positive regulation of leukocyte migration; cell-matrix adhesion; blood coagulation; cell adhesion
Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
Research Articles on ITGA2B
1. post-treatment of peptides derived from the full-length tail or from the turn motif did not reverse aIIb and aV integrin activation.
Precautions
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Disclaimer
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