Full Product Name
NSD1 Antibody
Product Synonym Names
Mouse monoclonal IgG to NSD1
Product Gene Name
anti-NSD1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96L73
Purity/Purification
Protein G-Sepharose affinity purified.
Immunogen
Recombinant fragment of Human NSD1 (Internal).
Preservative
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Cellular Localization
Nucleus
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-NSD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NSD1 antibody
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator.
Product Categories/Family for anti-NSD1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-NSD1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NSD1 antibody
ELISA: 1:5000-1:20000
WB: 1:100-1:2000
Testing Data of anti-NSD1 antibody
NCBI/Uniprot data below describe general gene information for NSD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071900.2
[Other Products]
NCBI GenBank Nucleotide #
NM_022455
[Other Products]
UniProt Primary Accession #
Q96L73
[Other Products]
UniProt Secondary Accession #
Q96PD8; Q96RN7[Other Products]
UniProt Related Accession #
Q96L73[Other Products]
Molecular Weight
284,264 Da
NCBI Official Full Name
histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform b
NCBI Official Synonym Full Names
nuclear receptor binding SET domain protein 1
NCBI Official Symbol
NSD1 [Similar Products]
NCBI Official Synonym Symbols
STO; KMT3B; SOTOS; ARA267; SOTOS1
[Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
UniProt Protein Name
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
UniProt Synonym Protein Names
Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltransferase 3B; Nuclear receptor-binding SET domain-containing protein 1; NR-binding SET domain-containing protein
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
NSD1 [Similar Products]
UniProt Synonym Gene Names
ARA267; KMT3B; NR-binding SET domain-containing protein [Similar Products]
NCBI Summary for NSD1
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for NSD1
Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
Research Articles on NSD1
1. Intratumoral heterogeneity (ITH) of NSD1 mutation in a colorectal cancers suggests that NSD1 mutation occurred during tumour progression rather than as an early event.
Precautions
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Disclaimer
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