Product Name
gamma sarcoglycan (SGCG), Polyclonal Antibody
Full Product Name
Anti-gamma sarcoglycan Antibody
Product Gene Name
anti-SGCG antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13326
Purity/Purification
Affinity Purified
Concentration
100ug/200ul (lot specific)
Storage Buffer
Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-SGCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SGCG antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SGCG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000222.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000231.2
[Other Products]
UniProt Primary Accession #
Q13326
[Other Products]
UniProt Secondary Accession #
Q32M32; Q5T9J6[Other Products]
UniProt Related Accession #
Q13326[Other Products]
Molecular Weight
32,379 Da[Similar Products]
NCBI Official Full Name
gamma-sarcoglycan
NCBI Official Synonym Full Names
sarcoglycan gamma
NCBI Official Symbol
SGCG [Similar Products]
NCBI Official Synonym Symbols
A4; MAM; DMDA; SCG3; 35DAG; DAGA4; DMDA1; LGMD2C; SCARMD2; gamma-SG
[Similar Products]
NCBI Protein Information
gamma-sarcoglycan
UniProt Protein Name
Gamma-sarcoglycan
UniProt Synonym Protein Names
35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family
Gamma-sarcoglycan
UniProt Gene Name
SGCG [Similar Products]
UniProt Synonym Gene Names
Gamma-SG; 35DAG [Similar Products]
NCBI Summary for SGCG
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
UniProt Comments for SGCG
SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Protein type: Dystrophin complex; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q12.12
Cellular Component: plasma membrane; sarcolemma
Molecular Function: protein binding
Biological Process: cardiac muscle development; heart contraction; muscle cell development; muscle development
Disease: Muscular Dystrophy, Limb-girdle, Type 2c
Research Articles on SGCG
1. These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
