Product Name
RNT2 (RNASET2), Blocking Peptide
Product Synonym Names
Ribonuclease T2; 3127-; Ribonuclease 6; RNASET2; RNASE6PL
Product Gene Name
RNASET2 blocking peptide
[Similar Products]
Product Synonym Gene Name
RNASE6PL[Similar Products]
Antibody/Peptide Pairs
RNT2 peptide (MBS9217856) is used for blocking the activity of RNT2 antibody (MBS9201427)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O00584
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note: Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction
Tissue Location
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of RNASET2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RNASET2 blocking peptide
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.
NCBI/Uniprot data below describe general gene information for RNASET2. It may not necessarily be applicable to this product.
NCBI Accession #
O00584.2
[Other Products]
UniProt Primary Accession #
O00584
[Other Products]
UniProt Secondary Accession #
Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47; B2RDA7; E1P5C3[Other Products]
UniProt Related Accession #
O00584[Other Products]
Molecular Weight
14,000 Da
NCBI Official Full Name
Ribonuclease T2
NCBI Official Synonym Full Names
ribonuclease T2
NCBI Official Symbol
RNASET2 [Similar Products]
NCBI Official Synonym Symbols
RNASE6PL; bA514O12.3
[Similar Products]
NCBI Protein Information
ribonuclease T2
UniProt Protein Name
Ribonuclease T2
UniProt Synonym Protein Names
Ribonuclease 6
Protein Family
Ribonuclease
UniProt Gene Name
RNASET2 [Similar Products]
UniProt Synonym Gene Names
RNASE6PL [Similar Products]
UniProt Entry Name
RNT2_HUMAN
NCBI Summary for RNASET2
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
UniProt Comments for RNASET2
RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Ribonuclease; EC 3.1.27.-; Secreted, signal peptide; RNA-binding
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; lysosome
Molecular Function: ribonuclease activity
Biological Process: RNA catabolic process
Disease: Leukoencephalopathy, Cystic, Without Megalencephaly
Research Articles on RNASET2
1. Biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation.
Precautions
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Disclaimer
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