Full Product Name
SGCG Polyclonal Antibody
Product Synonym Names
A4; MAM; DMDA; SCG3; TYPE; DAGA4; DMDA1; LGMD2C; SCARMD2
Product Gene Name
anti-SGCG antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13326
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human SGCG
Calculated Molecular Weight
32kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-SGCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGCG antibody
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
Product Categories/Family for anti-SGCG antibody
Polyclonal
Applications Tested/Suitable for anti-SGCG antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SGCG antibody
WB: 1:200-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-SGCG antibody
Western blot analysis of extracts of MCF-7 cells, using SGCG antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
NCBI/Uniprot data below describe general gene information for SGCG. It may not necessarily be applicable to this product.
NCBI Accession #
Q13326.4
[Other Products]
UniProt Primary Accession #
Q13326
[Other Products]
UniProt Secondary Accession #
Q32M32; Q5T9J6[Other Products]
UniProt Related Accession #
Q13326[Other Products]
NCBI Official Full Name
Gamma-sarcoglycan
NCBI Official Synonym Full Names
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
NCBI Official Symbol
SGCG [Similar Products]
NCBI Official Synonym Symbols
A4; MAM; DMDA; SCG3; TYPE; DAGA4; DMDA1; LGMD2C; SCARMD2
[Similar Products]
NCBI Protein Information
gamma-sarcoglycan; 35DAG; gamma-SG; gamma sarcoglycan; 35kD dystrophin-associated glycoprotein; 35 kDa dystrophin-associated glycoprotein
UniProt Protein Name
Gamma-sarcoglycan
UniProt Synonym Protein Names
35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family
Gamma-sarcoglycan
UniProt Gene Name
SGCG [Similar Products]
UniProt Synonym Gene Names
Gamma-SG; 35DAG [Similar Products]
UniProt Entry Name
SGCG_HUMAN
NCBI Summary for SGCG
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
UniProt Comments for SGCG
SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Protein type: Membrane protein, integral; Dystrophin complex
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: cytoskeleton; cytoplasm; plasma membrane; integral to membrane; sarcoglycan complex; sarcolemma
Molecular Function: protein binding
Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development
Disease: Muscular Dystrophy, Limb-girdle, Type 2c
Research Articles on SGCG
1. A report of two siblings with severe childhood onset limb-girdle muscular dystrophy type 2C supports the theory that the mutation G787A in the SGCG gene is a founder mutation.
Precautions
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