Product Name
Non-lysosomal glucosylceramidase (Gba2), Recombinant Protein
Full Product Name
Recombinant Mouse Non-lysosomal glucosylceramidase (Gba2) , partial
Product Gene Name
Gba2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Gba2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q69ZF3
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Gba2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Gba2 recombinant protein
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
NCBI/Uniprot data below describe general gene information for Gba2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_766280.2
[Other Products]
NCBI GenBank Nucleotide #
NM_172692.3
[Other Products]
UniProt Primary Accession #
Q69ZF3
[Other Products]
UniProt Secondary Accession #
Q6PGM3; Q8BTN9[Other Products]
UniProt Related Accession #
Q69ZF3[Other Products]
Molecular Weight
103,294 Da
NCBI Official Full Name
non-lysosomal glucosylceramidase
NCBI Official Synonym Full Names
glucosidase beta 2
NCBI Official Symbol
Gba2 [Similar Products]
NCBI Official Synonym Symbols
F630034E04
[Similar Products]
NCBI Protein Information
non-lysosomal glucosylceramidase
UniProt Protein Name
Non-lysosomal glucosylceramidase
UniProt Synonym Protein Names
Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2
UniProt Gene Name
Gba2 [Similar Products]
UniProt Synonym Gene Names
Kiaa1605; NLGase; Beta-glucosidase 2 [Similar Products]
UniProt Comments for Gba2
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development (). Required for proper formation of motor neuron axons ().
Research Articles on Gba2
1. sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
