Product Name
papillary renal cell carcinoma (PRCC), Polyclonal Antibody
Full Product Name
Rabbit anti-human papillary renal cell carcinoma (translocation-associated) polyclonal Antibody
Product Synonym Names
papillary renal cell carcinoma (translocation-associated); PRCC; MGC17178; MGC4723; RCCP1; TPRC
Product Gene Name
anti-PRCC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21253 / sc-21254
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PRCC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PRCC antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PRCC. It may not necessarily be applicable to this product.
NCBI Accession #
AAH04913.1
[Other Products]
UniProt Secondary Accession #
O00665; O00724; Q5SZ06; A8K1F7[Other Products]
UniProt Related Accession #
Q92733[Other Products]
Molecular Weight
52,418 Da[Similar Products]
NCBI Official Full Name
Papillary renal cell carcinoma (translocation-associated)
NCBI Official Synonym Full Names
papillary renal cell carcinoma (translocation-associated)
NCBI Official Symbol
PRCC [Similar Products]
NCBI Official Synonym Symbols
TPRC; RCCP1
[Similar Products]
NCBI Protein Information
proline-rich protein PRCC; papillary renal cell carcinoma translocation-associated gene protein
UniProt Protein Name
Proline-rich protein PRCC
UniProt Synonym Protein Names
Papillary renal cell carcinoma translocation-associated gene protein
Protein Family
Proline-rich protein
UniProt Gene Name
PRCC [Similar Products]
UniProt Synonym Gene Names
TPRC [Similar Products]
UniProt Entry Name
PRCC_HUMAN
NCBI Summary for PRCC
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
UniProt Comments for PRCC
PRCC: May regulate cell cycle progression through interaction with MAD2L2. A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleus
Molecular Function: protein binding
Biological Process: mitotic cell cycle checkpoint
Disease: Renal Cell Carcinoma, Papillary, 1
Research Articles on PRCC
1. Our data suggest a scenario in which, during the course of renal cell carcinoma development, an initial PRCCTFE3-induced cell cycle delay must be numbed, thus permitting continued proliferation and progression towards full-blown malignancy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
