Full Product Name
CTDP1, NT (RNA Polymerase II Subunit A C-terminal Domain Phosphatase, TFIIF-associating CTD Phosphatase, FCP1)
Product Synonym Names
Anti -CTDP1, NT (RNA Polymerase II Subunit A C-terminal Domain Phosphatase, TFIIF-associating CTD Phosphatase, FCP1)
Product Gene Name
anti-CTDP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 18; NC_000018.9 (77439801..77514507). Location: 18q23
3D Structure
ModBase 3D Structure for Q9Y5B0
Specificity
Recognizes human CTDP1.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the N-terminal region of human CTDP1 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CTDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTDP1 antibody
CTDP1 is a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex.
Product Categories/Family for anti-CTDP1 antibody
Antibodies; Abs to Enzymes, Phosphatase
Applications Tested/Suitable for anti-CTDP1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CTDP1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
NCBI/Uniprot data below describe general gene information for CTDP1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q9Y5B0
[Other Products]
UniProt Secondary Accession #
Q7Z644; Q96BZ1; Q9Y6F5; A8MY97[Other Products]
UniProt Related Accession #
Q9Y5B0[Other Products]
Molecular Weight
104,399 Da[Similar Products]
NCBI Official Full Name
CTDP1 protein
NCBI Official Synonym Full Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
NCBI Official Symbol
CTDP1 [Similar Products]
NCBI Official Synonym Symbols
FCP1; CCFDN
[Similar Products]
NCBI Protein Information
RNA polymerase II subunit A C-terminal domain phosphatase; OTTHUMP00000163841; OTTHUMP00000163842; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase 1; CTD of POLR2A, phosphatase of, subunit 1; transcription factor IIF-associating CTD phosphatase 1
UniProt Protein Name
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Synonym Protein Names
TFIIF-associating CTD phosphatase
UniProt Gene Name
CTDP1 [Similar Products]
UniProt Synonym Gene Names
FCP1 [Similar Products]
UniProt Entry Name
CTDP1_HUMAN
NCBI Summary for CTDP1
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
UniProt Comments for CTDP1
CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; spindle; spindle midzone; midbody; actin cytoskeleton
Molecular Function: DNA-directed RNA polymerase activity; CTD phosphatase activity
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; cell division; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; protein amino acid dephosphorylation; exit from mitosis
Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Research Articles on CTDP1
1. NMR assignments for C terminal region
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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