MC1R, Monoclonal Antibody

Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R; MC1R; MSHR

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgM

578CT6.2.3

Mouse

This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Vial Concentration: 2 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-MC1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This intronless gene encodes the receptor protein for
melanocyte-stimulating hormone (MSH). The encoded protein, a seven
pass transmembrane G protein coupled receptor, controls
melanogenesis. Two types of melanin exist: red pheomelanin and
black eumelanin. Gene mutations that lead to a loss in function are
associated with increased pheomelanin production, which leads to
lighter skin and hair color. Eumelanin is photoprotective but
pheomelanin may contribute to UV-induced skin damage by generating
free radicals upon UV radiation. Binding of MSH to its receptor
activates the receptor and stimulates eumelanin synthesis. This
receptor is a major determining factor in sun sensitivity and is a
genetic risk factor for melanoma and non-melanoma skin cancer. Over
30 variant alleles have been identified which correlate with skin
and hair color, providing evidence that this gene is an important
component in determining normal human pigment variation. [provided
by RefSeq].

Metabolism; Neuroscience; Signal Transduction; GPCR Antibodies

Western Blot (WB), ELISA (EIA)

WB~~1:100~250

MC1R Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the MC1R antibody detected the MC1R protein (arrow).

34706

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

melanocyte-stimulating hormone receptor

Melanocyte-stimulating hormone receptor

MSHR; MSH-R; MC1-R  [Similar Products]

MSHR_HUMAN

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

MC1R: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; hormone binding; melanocortin receptor activity; ubiquitin protein ligase binding; melanocyte stimulating hormone receptor activity; peptide receptor activity, G-protein coupled

Biological Process: melanin biosynthetic process; positive regulation of protein kinase B signaling cascade; G-protein signaling, coupled to cyclic nucleotide second messenger; pigmentation; UV protection; multicellular organismal development; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; sensory perception of pain

Disease: Albinism, Oculocutaneous, Type Ii; Melanoma, Cutaneous Malignant, Susceptibility To, 5; Increased Analgesia From Kappa-opioid Receptor Agonist, Female-specific; Skin/hair/eye Pigmentation, Variation In, 2

Demenais, F., et al. J. Natl. Cancer Inst. 102(20):1568-1583(2010)
Strange, R.C., et al. Mult. Scler. 16(9):1109-1116(2010)
Ibarrola-Villava, M., et al. Exp. Dermatol. 19(9):836-844(2010)
Smith, G., et al. Pharmacogenet. Genomics (2010) In press :
Kricker, A., et al. Cancer Causes Control (2010) In press :

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