spastic paraplegia 20 (Troyer syndrome), ELISA Kit

Mouse Spartin (SPG20) ELISA kit; KIAA0610; SPARTIN; TAHCCP1; spartin; trans-activated by hepatitis C virus core protein 1; spastic paraplegia 20 (Troyer syndrome)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SPG20 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9321141 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the spastic paraplegia 20 (Troyer syndrome) (SPG20) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SPG20. The ELISA analytical biochemical technique of the MBS9321141 kit is based on SPG20 antibody-SPG20 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SPG20 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SPG20. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

66,450 Da

spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)

spartin

Spartin

Kiaa0610  [Similar Products]

SPG20_MOUSE

SPG20: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Defects in SPG20 are the cause of spastic paraplegia autosomal recessive type 20 (SPG20); also known as Troyer syndrome (TRS). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature.

Protein type: Unknown function

Cellular Component: mitochondrial outer membrane; cytoplasm; synapse; lipid particle

Molecular Function: protein binding

Biological Process: regulation of mitochondrial membrane potential; negative regulation of collateral sprouting in the absence of injury; neuromuscular process; cytokinesis; negative regulation of BMP signaling pathway

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