Full Product Name
CBX2 Antibody
Product Gene Name
anti-CBX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AC105337 Genomic DNA
3D Structure
ModBase 3D Structure for Q14781
Species Reactivity
Human, Mouse
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CBX2 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CBX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005180.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005189.2
[Other Products]
UniProt Primary Accession #
Q14781
[Other Products]
UniProt Secondary Accession #
Q0VDA5; Q9BTB1[Other Products]
UniProt Related Accession #
Q14781[Other Products]
Molecular Weight
23,312 Da
NCBI Official Full Name
chromobox protein homolog 2 isoform 1
NCBI Official Synonym Full Names
chromobox 2
NCBI Official Symbol
CBX2 [Similar Products]
NCBI Official Synonym Symbols
M33; CDCA6; SRXY5
[Similar Products]
NCBI Protein Information
chromobox protein homolog 2
UniProt Protein Name
Chromobox protein homolog 2
Protein Family
Chromobox protein
UniProt Gene Name
CBX2 [Similar Products]
NCBI Summary for CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for CBX2
CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Molecular Function: protein binding
Biological Process: development of primary sexual characteristics; negative regulation of transcription from RNA polymerase II promoter; protein sumoylation
Disease: 46,xy Sex Reversal 5
Research Articles on CBX2
1. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2.
Precautions
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Disclaimer
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