Elongation of Very Long Chain Fatty Acids Like Protein 1, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ELOVL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS078846 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Elongation of Very Long Chain Fatty Acids Like Protein 1 (ELOVL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ELOVL1. The ELISA analytical biochemical technique of the MBS078846 kit is based on ELOVL1 antibody-ELOVL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ELOVL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ELOVL1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

36,829 Da

ELOVL fatty acid elongase 4

elongation of very long chain fatty acids protein 4; ELOVL FA elongase 4; cancer/testis antigen 118; 3-keto acyl-CoA synthase ELOVL4; very-long-chain 3-oxoacyl-CoA synthase 4; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4

Elongation of very long chain fatty acids protein 4

ELOVL FA elongase 4  [Similar Products]

ELOV4_HUMAN

This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]

ELOVL4: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Defects in ELOVL4 are the cause of ichthyosis, spastic quadriplegia, and mental retardation (ISQMR). A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures. Belongs to the ELO family.

Protein type: Cancer Testis Antigen (CTA); Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; EC 2.3.1.199

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: transferase activity; protein binding; G-protein coupled photoreceptor activity

Biological Process: very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; fatty acid elongation, saturated fatty acid; cellular lipid metabolic process; fatty acid biosynthetic process; detection of visible light

Disease: Spinocerebellar Ataxia 34

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