Full Product Name
CBX2, NT (CBX2, Chromobox protein homolog 2)
Product Synonym Names
Anti -CBX2, NT (CBX2, Chromobox protein homolog 2)
Product Gene Name
anti-CBX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (77751977..77761449). Location: 17q25.3
3D Structure
ModBase 3D Structure for Q14781
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CBX2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CBX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CBX2 antibody
CBX2 is a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones.
Product Categories/Family for anti-CBX2 antibody
Antibodies; Abs to Chromatin Proteins
Applications Tested/Suitable for anti-CBX2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CBX2 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for CBX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005180.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005189.2
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UniProt Primary Accession #
Q14781
[Other Products]
UniProt Secondary Accession #
Q0VDA5; Q9BTB1[Other Products]
UniProt Related Accession #
Q14781[Other Products]
Molecular Weight
56,081 Da[Similar Products]
NCBI Official Full Name
chromobox protein homolog 2 isoform 1
NCBI Official Synonym Full Names
chromobox homolog 2
NCBI Official Symbol
CBX2 [Similar Products]
NCBI Official Synonym Symbols
M33; CDCA6; SRXY5
[Similar Products]
NCBI Protein Information
chromobox protein homolog 2; modifier 3; Pc class homolog; cell division cycle associated 6; chromobox homolog 2 (Pc class homolog, Drosophila)
UniProt Protein Name
Chromobox protein homolog 2
Protein Family
Chromobox protein
UniProt Gene Name
CBX2 [Similar Products]
UniProt Entry Name
CBX2_HUMAN
NCBI Summary for CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for CBX2
CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; heterochromatin; euchromatin; PcG protein complex; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; cell differentiation; development of primary sexual characteristics
Disease: 46,xy Sex Reversal 5
Research Articles on CBX2
1. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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