Product Name
CACNA2D1, Blocking Peptide
Full Product Name
CACNA2D1 Antibody (N-term) Blocking Peptide
Product Synonym Names
Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1; CACNA2D1; CACNL2A; CCHL2A; MHS3
Product Gene Name
CACNA2D1 blocking peptide
[Similar Products]
Product Synonym Gene Name
CACNL2A; CCHL2A; MHS3[Similar Products]
Antibody/Peptide Pairs
CACNA2D1 peptide (MBS9227797) is used for blocking the activity of CACNA2D1 antibody (MBS9209991)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54289
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CACNA2D1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Single-pass type I membrane protein
Tissue Location
Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells Isoform 3, isoform 4 and isoform 5 are expressed in the aorta
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CACNA2D1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CACNA2D1 blocking peptide
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
NCBI/Uniprot data below describe general gene information for CACNA2D1. It may not necessarily be applicable to this product.
NCBI Accession #
P54289.3
[Other Products]
UniProt Primary Accession #
P54289
[Other Products]
UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
122,443 Da
NCBI Official Full Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1 [Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNA2D1 [Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3 [Similar Products]
UniProt Entry Name
CA2D1_HUMAN
NCBI Summary for CACNA2D1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for CACNA2D1
CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: plasma membrane; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity
Biological Process: calcium ion transport; regulation of calcium ion transport
Research Articles on CACNA2D1
1. detected a joint effect of SNP and G x E interaction in BMP2 and CACNA2D1 for depressive state.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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