Product Name
CaValpha2delta1, Polyclonal Antibody
Full Product Name
CaValpha2delta1 Polyclonal Antibody
Product Gene Name
anti-CaValpha2delta1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P54289
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Immunogen
Synthetic Peptide
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CaValpha2delta1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CaValpha2delta1 antibody
CACNA2D1 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1) is a Protein Coding gene. Diseases associated with CACNA2D1 include Familial Short Qt Syndrome and Timothy Syndrome. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and calcium channel regulator activity. An important paralog of this gene is CACNA2D2.The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
Applications Tested/Suitable for anti-CaValpha2delta1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CaValpha2delta1 antibody
WB: 1:500-1:2000
IHC: 1:100-1:300 ELISA: 1:40000
Western Blot (WB) of anti-CaValpha2delta1 antibody
Western Blot analysis of Rat brain using CaValpha2delta1 Polyclonal Antibody at dilution of 1:2000.
Immunohistochemistry (IHC) of anti-CaValpha2delta1 antibody
Immunohistochemistry of paraffin-embedded Rat brain tissue using CaValpha2delta1 Polyclonal Antibody at dilution of 1:200.
NCBI/Uniprot data below describe general gene information for CaValpha2delta1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000713.2
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NCBI GenBank Nucleotide #
NM_000722.3
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UniProt Primary Accession #
P54289
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UniProt Secondary Accession #
Q17R45; Q9UD80; Q9UD81; Q9UD82[Other Products]
UniProt Related Accession #
P54289[Other Products]
Molecular Weight
100-130kDa
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit alpha2delta 1
NCBI Official Symbol
CACNA2D1 [Similar Products]
NCBI Official Synonym Symbols
CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3
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NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-1
UniProt Gene Name
CACNA2D1 [Similar Products]
UniProt Synonym Gene Names
CACNL2A; CCHL2A; MHS3 [Similar Products]
NCBI Summary for CaValpha2delta1
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
UniProt Comments for CaValpha2delta1
CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q21.11
Cellular Component: plasma membrane; sarcoplasmic reticulum; voltage-gated calcium channel complex
Molecular Function: metal ion binding; voltage-gated calcium channel activity
Biological Process: calcium ion transport; regulation of calcium ion transport
Research Articles on CaValpha2delta1
1. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction
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