Full Product Name
IGBP1 Rabbit Polyclonal
Product Gene Name
anti-IGBP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Immunoglobulin (CD79A) binding protein 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-IGBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IGBP1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IGBP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001542.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001551.2
[Other Products]
UniProt Secondary Accession #
Q8TAB2[Other Products]
UniProt Related Accession #
P78318[Other Products]
Molecular Weight
39,222 Da
NCBI Official Full Name
immunoglobulin-binding protein 1
NCBI Official Synonym Full Names
immunoglobulin (CD79A) binding protein 1
NCBI Official Symbol
IGBP1 [Similar Products]
NCBI Official Synonym Symbols
IBP1; ALPHA-4
[Similar Products]
NCBI Protein Information
immunoglobulin-binding protein 1
UniProt Protein Name
Immunoglobulin-binding protein 1
UniProt Synonym Protein Names
B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16
Protein Family
Immunoglobulin-binding protein
UniProt Gene Name
IGBP1 [Similar Products]
UniProt Synonym Gene Names
IBP1; Protein alpha-4 [Similar Products]
UniProt Entry Name
IGBP1_HUMAN
NCBI Summary for IGBP1
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Comments for IGBP1
IGBP1: Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family.
Protein type: Phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq13.1-q13.3
Cellular Component: cytoplasm; cytosol; microtubule
Molecular Function: mitogen-activated protein kinase kinase binding; protein binding; protein complex binding; protein domain specific binding; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity
Biological Process: B cell activation; negative regulation of caspase activity; negative regulation of protein amino acid dephosphorylation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of protein phosphatase type 2A activity; signal transduction
Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
Research Articles on IGBP1
1. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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