Cardiotrophin Like Cytokine Factor 1 (CLCF1), Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 19; NC_000085.6 (4214392..4222615). Location: 19 A; 19

E.coli

>98%

20 mM Tris, 150 mM NaCI,pH8.0 containing 0.01% sarcosyl, 5% Trehalose.

Original Concentration: 200 ug/mL (lot specific)

Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8°C for one month.
Aliquot and store at -80°C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of CLCF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Positive Control; Immunogen; SDS-PAGE; WB.

(May be suitable for use in other assays to be determined by the end user.)

cardiotrophin-like cytokine factor 1

cardiotrophin-like cytokine factor 1; BSF-3; NNT-1; NNT-1/BSF-3; novel neurotrophin-1; B-cell stimulating factor 3; B-cell-stimulating factor 3; b cell-stimulating factor 3; neurotrophin-1/B-cell stimulating factor-3

Cardiotrophin-like cytokine factor 1

Bsf3; Nnt1; BSF-3; NNT-1  [Similar Products]

CLCF1_MOUSE

CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Apoptosis

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: protein binding; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding

Biological Process: positive regulation of T-helper 2 type immune response; regulation of protein kinase B signaling cascade; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of corticotropin-releasing hormone secretion; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; regulation of inflammatory response; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation

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