CLCF1, Polyclonal Antibody

Rabbit Polyclonal to Human CLCF1; CLCF1; B-cell stimulating factor 3; BSF-3; BSF3; CISS2; NR6; Novel neurotrophin-1; NNT1; B-cell stimulatory factor 3; B-cell-stimulating factor 3; NNT-1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human NNT-1/BCSF-3

Immunoaffinity Purified

Lyophilized from PBS, pH 7.2

Store Lyophilized at room temperature up to 1 month.
Reconstituted for up to two weeks at 2-8 degree C.
Aliquot and freeze at -20 degree C for long term storage.
Avoid freeze/thaw cycles.

Small volumes of anti-CLCF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CLCF1 is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms aheterodimer complex with cytokine receptor-like factor 1 (CRLF1). Thisdimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activatesthe Jak-STAT signaling cascade. CLCF1 can be actively secreted fromcells by forming a complex with soluble type I CRLF1 or soluble CNTFR.

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 0.5-2 ug/ml
IHC-P: 5 ug/ml
WB: 0.1-0.2 ug/ml

Anti-CLCF1 antibody IHC of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

24,087 Da

cardiotrophin like cytokine factor 1

cardiotrophin-like cytokine factor 1

Cardiotrophin-like cytokine factor 1

BSF3; CLC; NNT1; BSF-3; NNT-1  [Similar Products]

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.

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