Full Product Name
TTBK2 Polyclonal Antibody
Product Synonym Names
SCA11; TTBK
Product Gene Name
anti-TTBK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
LGRSKSPPSH SGSSSSRRSC QQEHCKPSKN GLKGSGSLHH HSASTKTPQG KSKPASKLSR
3D Structure
ModBase 3D Structure for Q6IQ55
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human TTBK2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Cell projection, Cytoplasm, Nucleus, centriole, centrosome, cilium, cilium basal body, cytoskeleton, cytosol, microtubule organizing center
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-TTBK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TTBK2 antibody
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Product Categories/Family for anti-TTBK2 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-TTBK2 antibody
Immunofluorescence (IF)
Application Notes for anti-TTBK2 antibody
IF: 1:50 - 1:200
Immunofluorescence (IF) of anti-TTBK2 antibody
Immunofluorescence analysis of A549 cells using TTBK2 antibody. Blue: DAPI for nuclear staining.
NCBI/Uniprot data below describe general gene information for TTBK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775771.3
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NCBI GenBank Nucleotide #
NM_173500.3
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UniProt Primary Accession #
Q6IQ55
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UniProt Secondary Accession #
O94932; Q6ZN52; Q8IVV1[Other Products]
UniProt Related Accession #
Q6IQ55[Other Products]
Molecular Weight
54kDa/129kDa/137kDa
NCBI Official Full Name
tau-tubulin kinase 2
NCBI Official Synonym Full Names
tau tubulin kinase 2
NCBI Official Symbol
TTBK2 [Similar Products]
NCBI Official Synonym Symbols
TTBK; SCA11
[Similar Products]
NCBI Protein Information
tau-tubulin kinase 2
UniProt Protein Name
Tau-tubulin kinase 2
Protein Family
Tau-tubulin kinase
UniProt Gene Name
TTBK2 [Similar Products]
UniProt Synonym Gene Names
KIAA0847 [Similar Products]
NCBI Summary for TTBK2
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
UniProt Comments for TTBK2
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Research Articles on TTBK2
1. Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis in glioma cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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