Full Product Name
MPV17 Antibody (N-term)
Product Synonym Names
Protein Mpv17; MPV17
Product Gene Name
anti-MPV17 antibody
[Similar Products]
Antibody/Peptide Pairs
MPV17 peptide (MBS9227829) is used for blocking the activity of MPV17 antibody (MBS9214436)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
24-50
3D Structure
ModBase 3D Structure for P39210
Specificity
This MPV17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-50 amino acids from the N-terminal region of human MPV17.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MPV17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MPV17 antibody
MPV17 is a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species.
Product Categories/Family for anti-MPV17 antibody
Metabolism; Signal Transduction
Applications Tested/Suitable for anti-MPV17 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-MPV17 antibody
WB~~1:1000
Western Blot (WB) of anti-MPV17 antibody
Western blot analysis of MPV17 Antibody (N-term) in Hela cell line lysates (35ug/lane). MPV17 (arrow) was detected using the purified Pab.
Immunohistochemistry (IHC) of anti-MPV17 antibody
Formalin-fixed and paraffin-embedded human brain tissue reacted with MPV17 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Flow Cytometry (FC/FACS) of anti-MPV17 antibody
MPV17 Antibody (N-term) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
NCBI/Uniprot data below describe general gene information for MPV17. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002428.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002437.4
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UniProt Primary Accession #
P39210
[Other Products]
UniProt Secondary Accession #
Q53SY2; Q96B08; D6W555[Other Products]
UniProt Related Accession #
P39210; AAB25210[Other Products]
NCBI Official Full Name
protein Mpv17
NCBI Official Synonym Full Names
MpV17 mitochondrial inner membrane protein
NCBI Official Symbol
MPV17 [Similar Products]
NCBI Official Synonym Symbols
SYM1; MTDPS6
[Similar Products]
NCBI Protein Information
protein Mpv17
UniProt Protein Name
Protein Mpv17
Protein Family
Mpv17-like protein
UniProt Gene Name
MPV17 [Similar Products]
UniProt Entry Name
MPV17_HUMAN
NCBI Summary for MPV17
This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
UniProt Comments for MPV17
MPV17: Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Defects in MPV17 are the cause of mitochondrial DNA depletion syndrome type 6 (MTDPS6). A disease characterized by infantile onset of progressive liver failure, often leading to death in the first year of life, peripheral neuropathy, corneal scarring, acral ulceration and osteomyelitis leading to autoamputation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Belongs to the peroxisomal membrane protein PXMP2/4 family.
Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; peroxisome
Biological Process: mitochondrial genome maintenance; homeostatic process; glomerular basement membrane development; inner ear development
Disease: Mitochondrial Dna Depletion Syndrome 6 (hepatocerebral Type)
Product References and Citations for anti-MPV17 antibody
Iida,R., et.al., J. Biol. Chem. 278 (8), 6301-6306 (2003)
Karasawa,M., et.al., Hum. Mol. Genet. 2 (11), 1829-1834 (1993)
Research Articles on MPV17
1. 12 pathogenic mutations in mitochondrial DNA depletion syndrome in the MPV17 gene, of which 11 are novel, in 17 patients from 12 families.
Precautions
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Disclaimer
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