Product Name
BCOR, cDNA Clone
Full Product Name
BCOR cDNA Clone
Product Gene Name
BCOR cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCTCTCAG CAACCCCCCT GTATGGGAAC GTTCACAGCT GGATGAACAG CGAGAGGGTC CGCATGTGTG GGGCGAGCGA AGACAGGAAA ATCCTTGTAA ATGATGGTGA CGCTTCAAAA GCCAGACTGG AACTGAGGGA AGAGAATCCC TTGAACCACA ACGTGGTGGA TGCGAGCACG GCCCATAGGA TCGATGGCCT GGCAGCACTG AGCATGGACC GCACTGGCCT GATCCGGGAA GGGCTGCGGG TCCCGGGAAA CATCGTCTAT TCTAGCTTGT GTGGACTGGG CTCAGAGAAA GGTCGGGAGG CTGCCACAAG CACTCTAGGT GGCCTTGGGT TTTCTTCGGA AAGAAATCCA GAGATGCAGT TCAAACCGAA TACACCCGAG ACAGTGGAGG CTTCTGCCGT CTCTGGAAAA CCCCCAAATG GCTTCAGTGC TATATACAAA ACACCGCCTG GAATACAAAA AAGTGCTGTA GCCACAGCAG AAGCGCTGGG CTTGGACAGG CCTGCCAGCG ACAAACAGAG CCCTCTCAAC ATCAATGGTG CTAGTTATCT GCGGCTGCCC TGGGTCAATC CTTACATGGA GGGTGCCACG CCAGCCATCT ACCCTTTCCT CGACTCGCCA AATAAGTATT CACTGAACAT GTACAAGGCC TTGCTACCTC AGCAGTCCTA CAGCTTGGCC CAGCCGCTGT ATTCTCCAGT CTGCACCAAT GGGGAGCGCT TTCTCTACCT GCCGCCACCT CACTACGTCG GTCCCCACAT CCCATCGTCC TTGGCATCAC CCATGAGGCT CTCGACACCT TCGGCCTCCC CAGCCATCCC GCCTCTCGTC CATTGCGCAG ACAAAAGCCT CCCGTGGAAG ATGGGCGTCA GCCCTGGGAA TCCTGTTGAT TCCCACGCCT ATCCTCACAT CCAGAACAGT AAGCAGCCCA GGGTTCCCTC TGCCAAGGCG GTCACCAGTG GCCTGCCGGG GGACACAGCT CTCCTGTTGC CCCCCTCGCC TCGGCCGTCA CCCCGAGTCC ACCTTCCCAC CCAGCCTGCT GCAGACACCT ACTCGGAGTT CCACAAGCAC TATGCCAGGA TCTCCACCTC TCCTTCAGTT GCCCTGTCAA AGCCATACAT GACAGTTAGC AGCGAGTTCC CCGCGGCCAG GCTCTCCAAT GGCAAGTATC CCAAGGCTCC GGAAGGGGGC GAAGGTGCCC AGCCAGTGCC CGGGCATGCC CGGAAGACAG CGGTTCAAGA CAGAAAAGAC GGCAGCTCAC CTCCTCTGTT GGAGAAGCAG ACCGTTACCA AAGACGTCAC AGATAAGCCA CTAGACTTGT CTTCTAAAGT GGTGGATGTA GATGCTTCCA AAGCTGACCA CATGAAAAAG ATGGCTCCCA CGGTCCTGGT TCACAGCAGG GCTGGAAGTG GCTTAGTGCT CTCCGGAAGT GAGATTCCGA AAGAAACACT ATCTCCTCCA GGAAATGGTT GTGCTATCTA TAGATCTGAA ATCATCAGCA CTGCTCCCTC ATCCTGGGTG GTGCCCGGGC CAAGTCCTAA CGAAGAGAAC AATGGCAAAA GCATGTCGCT GAAAAACAAG GCATTGGACT GGGCGATACC ACAGCAGCGG AGTTCATCAT GCCCGCGCAT GGGCGGCACC GATGCTGTCA TCACTAACGT TTCAGGGTCA GTGTCGAGTG CGGGCCGCCC AGCCTCCGCA TCACCCGCCC CCAATGCCAA TGCAGATGGC ACCAAAACCA GCAGGAGCTC TGTAGAAACC ACACCATCCG TTATTCAGCA CGTGGGCCAG CCCCCGGCCA CTCCTGCCAA GCACAGTAGC AGCACCAGCA GCAAGGGCGC CAAAGCCAGC AACCCAGAAC CGAGTTTCAA AGCAAACGAG AACGGCCTTC CACCAAGCTC TATATTTCTG TCTCCAAATG AGGCATTCAG GTCCCCACCA ATTCCCTACC CCAGGAGTTA CCTCCCTTAC CCAGCCCCTG AGGGCATTGC TGTAAGTCCC CTCTCCTTAC ATGGCAAAGG ACCTGTCTAC CCTCACCCAG TTTTGTTACC CAATGGCAGT CTGTTTCCTG GGCACCTTGC CCCAAAGCCT GGGCTGCCCT ATGGGCTTCC CACCGGCCGT CCAGAGTTTG TGACCTACCA AGATGCCCTG GGGTTGGGCA TGGTGCATCC CATGTTGATA CCACACACGC CCATAGAGAT TACTAAAGAG GAGAAACCAG AGAGGAGATC CCGGTCCCAT GAGAGAGCCC GTTACGAGGA CCCAACCCTC CGGAATCGGT TTTCCGAGAT TTTGGAAACT AGCAGCACCA AGTTACATCC AGATGTCCCC ACCGACAAGA ACCTAAAGCC GAACCCCAAC TGGAATCAAG GGAAGACTGT TGTCAAAAGC GACAAGCTTG TCTACGTAGA CCTTCTCCGA GAAGAACCAG ATGCTAAAAC TGACACAAAC GTGTCCAAAC CCAGCTTTGC AGCAGAGAGT GTTGGCCAGA GCGCTGAGCC CCCCAAGCCC TCAGTTGAGC CGGCCCTGCA GCAGCACCGT GATTTCATCG CCCTGAGAGA GGAGTTGGGG CGCATCAGTG ACTTCCACGA AACTTATACT TTCAAACAGC CAGTCTTCAC CGTAAGCAAG GACAGTGTTC TGGCAGGTAC CAACAAAGAG AACCTAGGGT TGCCAGTCTC GACTCCATTC CTGGAGCCAC CTCTGGGGAG CGATGGCCCT GCTGTAACTT TTGGTAAAAC CCAAGAGGAT CCCAAACCAT TTTGTGTGGG CAGTGCCCCA CCAAGTGTGG ATGTGACCCC CACCTATACC AAAGATGGAG CTGATGAGGC TGAATCAAAT GATGGCAAAG TTCTGAAACC GAAGCCATCT AAGCTGGCAA AGAGAATCGC CAACTCAGCG GGTTACGTGG GTGACCGATT CAAATGTGTC ACTACCGAAC TGTATGCAGA TTCCAGTCAG CTCAGCCGGG AGCAACGGGC ATTGCAGGTG AGCCCCCCCA CCTGA
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BCOR cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BCOR. It may not necessarily be applicable to this product.
NCBI Accession #
BC128456
[Other Products]
UniProt Secondary Accession #
Q29RF6; Q6P4B6; Q7Z2K7; Q8TEB4; Q96DB3; Q9H232; Q9H233; Q9HCJ7; Q9NXF2; D3DWB3; D3DWB4[Other Products]
UniProt Related Accession #
Q6W2J9[Other Products]
Molecular Weight
186,235 Da
NCBI Official Full Name
Homo sapiens BCL6 co-repressor, mRNA
NCBI Official Synonym Full Names
BCL6 corepressor
NCBI Official Symbol
BCOR [Similar Products]
NCBI Official Synonym Symbols
MAA2; ANOP2; MCOPS2
[Similar Products]
NCBI Protein Information
BCL-6 corepressor
UniProt Protein Name
BCL-6 corepressor
Protein Family
BCL-6 corepressor
UniProt Gene Name
BCOR [Similar Products]
UniProt Synonym Gene Names
KIAA1575; BCoR [Similar Products]
UniProt Entry Name
BCOR_HUMAN
NCBI Summary for BCOR
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
UniProt Comments for BCOR
BCOR: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in ***** stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Belongs to the BCOR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: mitochondrion; nucleus; PcG protein complex
Molecular Function: heat shock protein binding; histone deacetylase binding; protein binding; transcription corepressor activity; transcription factor binding; ubiquitin-protein ligase activity
Biological Process: heart development; negative regulation of bone mineralization; negative regulation of histone H3-K36 methylation; negative regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis; palate development; specification of axis polarity
Disease: Microphthalmia, Syndromic 1; Microphthalmia, Syndromic 2
Research Articles on BCOR
1. Report mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney.
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Disclaimer
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