Product Name
Actinin-alpha2/3 (ACTN2), Polyclonal Antibody
Full Product Name
Actinin-alpha2/3 Polyclonal Antibody
Product Gene Name
anti-ACTN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35609
Other Notes
Small volumes of anti-ACTN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACTN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001094.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001103.3
[Other Products]
UniProt Primary Accession #
P35609
[Other Products]
UniProt Secondary Accession #
Q86TF4; Q86TI8; B1ANE4; B2RCS5[Other Products]
UniProt Related Accession #
P35609[Other Products]
Molecular Weight
103,920 Da[Similar Products]
NCBI Official Full Name
alpha-actinin-2 isoform 1
NCBI Official Synonym Full Names
actinin alpha 2
NCBI Official Symbol
ACTN2 [Similar Products]
NCBI Official Synonym Symbols
CMH23; CMD1AA
[Similar Products]
NCBI Protein Information
alpha-actinin-2
UniProt Protein Name
Alpha-actinin-2
UniProt Synonym Protein Names
Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
Protein Family
Alpha-actinin
UniProt Gene Name
ACTN2 [Similar Products]
NCBI Summary for ACTN2
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
UniProt Comments for ACTN2
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Research Articles on ACTN2
1. A dual-beam optical tweezers measured the mechanics of alpha-actinin 2 and rabbit titin interaction at the single-molecule level. Depending on the direction of force application, the unbinding forces can more than triple. Multiple alpha-actinin/Z-repeat interactions cooperate to ensure long-term stable titin anchoring, while allowing the individual components to exchange dynamically.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
