COMM domain-containing protein 1 (COMMD1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of COMMD1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7221256 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the COMM domain-containing protein 1 (COMMD1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COMMD1. The ELISA analytical biochemical technique of the MBS7221256 kit is based on COMMD1 antibody-COMMD1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COMMD1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COMMD1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

17,665 Da[Similar Products]

copper metabolism (Murr1) domain containing 1

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COMD1_HUMAN

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; recycling endosome; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleus

Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity; copper ion binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis

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