DNAH11, Polyclonal Antibody

Goat Anti-DNAH11 (aa 693-704) Antibody; DNAH11; dynein, axonemal, heavy chain 11; CILD7; DNAHBL; DNAHC11; DNHBL; DPL11; FLJ30095; FLJ37699; dynein, axonemal, heavy polypeptide 11; dynein, ciliary, heavy chain 11; dynein, heavy chain beta-like; CILD7 antibody; DNAHBL antibody; DNAHC11 antibody; DNHBL antibody; DPL11 antibody; dynein; axonemal; heavy chain 11 antibody; dynein; axonemal; heavy polypeptide 11 antibody; dynein; ciliary; heavy chain 11 antibody; dynein; heavy chain beta-like antibody; FLJ30095 antibody; FLJ37699 antibody; DNAH11 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-DNAH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 521kDa according to NP_003768.2. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.

520,369 Da

dynein axonemal heavy chain 11

dynein heavy chain 11, axonemal

Dynein heavy chain 11, axonemal

DYH11_HUMAN

This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]

DNAH11: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DNAH11 are a cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Defects in DNAH11 are the cause of primary ciliary dyskinesia type 7 (CILD7). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein heavy chain family.

Protein type: Motor; Microtubule-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p21

Cellular Component: cytoplasm; dynein complex; microtubule; motile primary cilium

Molecular Function: ATP binding; ATPase activity; microtubule motor activity

Biological Process: determination of left/right symmetry; heart development; metabolic process; sperm motility

Disease: Ciliary Dyskinesia, Primary, 7

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