Product Name
CRYBA4, cDNA Clone
Full Product Name
CRYBA4 cDNA Clone
Product Gene Name
CRYBA4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaccctgc aatgcacaaa gtcagcggga ccctggaaga tggtggtgtg ggatgaggac ggcttccagg gccggcggca cgagttcacg gccgagtgcc ccagcgtgct ggagcttggc ttcgagactg tgcgatcttt gaaagtgctg agtggagcgt gggtgggctt cgagcatgct ggcttccaag ggcagcagta cattctggaa cgaggcgaat atccaagctg ggatgcctgg ggcggcaaca cggcctaccc cgccgagagg ctcacctcct tccggcctgc ggcctgtgct aaccaccgtg actcgaggct gacaatcttc gagcaagaga acttcctggg caagaaagga gagctgagcg atgactatcc ttccctccag gccatgggat gggaaggcaa tgaagtaggg tccttccacg tccactctgg ggcctgggtt tgctcccagt ttccgggcta ccgaggattt cagtatgtgc tggaatgcga tcaccattcc ggtgactaca aacatttccg ggagtggggc tctcatgccc cgaccttcca ggtgcagagc atccgcagga tccagcagtg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CRYBA4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRYBA4. It may not necessarily be applicable to this product.
NCBI Accession #
BC069404
[Other Products]
UniProt Secondary Accession #
Q4VB22; Q6ICE4[Other Products]
UniProt Related Accession #
P53673[Other Products]
Molecular Weight
22,374 Da
NCBI Official Full Name
Homo sapiens crystallin, beta A4, mRNA
NCBI Official Synonym Full Names
crystallin beta A4
NCBI Official Symbol
CRYBA4 [Similar Products]
NCBI Official Synonym Symbols
CYRBA4; CTRCT23; MCOPCT4
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NCBI Protein Information
beta-crystallin A4
UniProt Protein Name
Beta-crystallin A4
UniProt Synonym Protein Names
Beta-A4 crystallin
Protein Family
Beta-crystallin
UniProt Gene Name
CRYBA4 [Similar Products]
UniProt Entry Name
CRBA4_HUMAN
NCBI Summary for CRYBA4
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
UniProt Comments for CRYBA4
CRYBA4: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family.
Chromosomal Location of Human Ortholog: 22q12.1
Molecular Function: protein binding
Biological Process: camera-type eye development; visual perception
Disease: Cataract 23
Research Articles on CRYBA4
1. rs2009066 located in the crystallin beta A4 (CRYBA4) gene was identified to be the most significantly associated with high myopia.
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Disclaimer
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