Product Name
Dynein, Axonemal, Heavy Chain 11 (DNAH11), Monoclonal Antibody
Full Product Name
Cy3-Linked Monoclonal Antibody to Dynein, Axonemal, Heavy Chain 11 (DNAH11)
Product Synonym Names
DNAHBL; DNAHC11; DNHBL; DPL11; Dynein, Heavy Chain Beta-Like; Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11
Product Gene Name
anti-DNAH11 antibody
[Similar Products]
Matching Pairs
Antibody: Dynein, Axonemal, Heavy Chain 11 (DNAH11) (MBS2110666)
Antigen: Dynein, Axonemal, Heavy Chain 11 (DNAH11) (MBS2105615)
Matching Pairs
Unconjugated Antibody: Dynein, Axonemal, Heavy Chain 11 (DNAH11) (MBS2111327)
Cy3 Conjugated Antibody: Dynein, Axonemal, Heavy Chain 11 (DNAH11) (MBS2110666)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Leu3896~As n4122
3D Structure
ModBase 3D Structure for Q96DT5
Specificity
The antibody is a mouse monoclonal antibody raised against DNAH11. It has been selected for its ability to recognize DNAH11 in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-DNAH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DNAH11 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for DNAH11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001264044.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001277115.2
[Other Products]
UniProt Primary Accession #
Q96DT5
[Other Products]
UniProt Related Accession #
Q96DT5[Other Products]
NCBI Official Full Name
dynein heavy chain 11, axonemal
NCBI Official Synonym Full Names
dynein axonemal heavy chain 11
NCBI Official Symbol
DNAH11 [Similar Products]
NCBI Official Synonym Symbols
CILD7; DNHBL; DPL11; DNAHBL; DNAHC11
[Similar Products]
NCBI Protein Information
dynein heavy chain 11, axonemal
UniProt Protein Name
Dynein heavy chain 11, axonemal
UniProt Synonym Protein Names
Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11
UniProt Gene Name
DNAH11 [Similar Products]
NCBI Summary for DNAH11
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
UniProt Comments for DNAH11
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Research Articles on DNAH11
1. Dnah11(avc)(4) did not disrupt SHF Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1(avc)(6) disrupted SHF Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.