Product Name
Neuroserpin (SERPINI1), Recombinant Protein
Full Product Name
Neuroserpin protein
Product Synonym Names
Serpin I1 protein; Protease inhibitor 12 protein
Product Gene Name
SERPINI1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Region of Neuroserpi n protein correspond ing to amino acids MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL.
3D Structure
ModBase 3D Structure for Q99574
Purity/Purification
> 96% pure
Form/Format
Supplied as a lyophilized powder.
Biological Significance
Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the ***** brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala.
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 ug/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of SERPINI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPINI1 recombinant protein
Purified recombinant Human Neuroserpin protein
Product Categories/Family for SERPINI1 recombinant protein
Neuroscience
Applications Tested/Suitable for SERPINI1 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.
NCBI Accession #
CAB03626.1
[Other Products]
UniProt Primary Accession #
Q99574
[Other Products]
UniProt Secondary Accession #
Q6AHZ4; A8K217; D3DNP1[Other Products]
Molecular Weight
44.6 kDa[Similar Products]
NCBI Official Full Name
neuroserpin
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
SERPINI1 [Similar Products]
UniProt Synonym Gene Names
PI12; PI-12 [Similar Products]
UniProt Entry Name
NEUS_HUMAN
UniProt Comments for SERPINI1
SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development
Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
