Product Name
neuroserpin antiserum (SERPINI1), Polyclonal Antibody
Full Product Name
Sheep anti mouse neuroserpin antiserum
Product Gene Name
anti-SERPINI1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3; NC_000069.6 (75557533..75642523). Location: 3 E3; 3
3D Structure
ModBase 3D Structure for O35684
Host
Host: Sheep; Source: Sheep serum
Purity/Purification
Serum
Form/Format
Frozen liquid
Concentration
Whole Antiserum (lot specific)
Immunogen
Recombinant full length mouse protein fused to a His tag at N-terminal end (Glycosylated).
Target Information
Recognises Neuroserpin
Target Molecular Weight
49000
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Other Notes
Small volumes of anti-SERPINI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SERPINI1 antibody
Polyclonal antiserum (host sheep) to mouse neuroserpin (His Tag).
Product Categories/Family for anti-SERPINI1 antibody
Neuroserpin; Polyclonal Antibodies to Mouse Neuroserpin
Applications Tested/Suitable for anti-SERPINI1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_033276.1
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NCBI GenBank Nucleotide #
NM_009250.2
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UniProt Primary Accession #
O35684
[Other Products]
UniProt Secondary Accession #
Q543F7; Q922U6[Other Products]
UniProt Related Accession #
O35684[Other Products]
Molecular Weight
46,348 Da
NCBI Official Full Name
neuroserpin
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade I, member 1
NCBI Official Symbol
Serpini1 [Similar Products]
NCBI Official Synonym Symbols
Ns; PI12; PI-12; Spi17; AI837402
[Similar Products]
NCBI Protein Information
neuroserpin; serpin I1; protease inhibitor 17; peptidase inhibitor 12; serine protease inhibitor 17
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serine protease inhibitor 17; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
Serpini1 [Similar Products]
UniProt Synonym Gene Names
Pi12; Spi17; PI-12 [Similar Products]
UniProt Entry Name
NEUS_MOUSE
UniProt Comments for SERPINI1
SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity
Biological Process: regulation of cell adhesion; negative regulation of peptidase activity
Research Articles on SERPINI1
1. Data indicate that the neuroprotective effect of neuroserpin is due to inhibition of plasmin-mediated excitotoxin-induced cell death and is independent of neuroserpin's ability to inhibit tissue plasminogen activator activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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