Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a), Polyclonal Antibody

ENaCa; ENaCalpha; SCNEA; SCNN1; Sodium Channel, Nonvoltage-Gated 1, Alpha; Epithelial Na (+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-SCNN1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

78,888 Da

sodium channel epithelial 1 alpha subunit

amiloride-sensitive sodium channel subunit alpha

Amiloride-sensitive sodium channel subunit alpha

Renac; Alpha-ENaC  [Similar Products]

acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006]

ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 4q42

Cellular Component: apical plasma membrane; cortical actin cytoskeleton; cytosol; external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane

Molecular Function: actin binding; amiloride-sensitive sodium channel activity; sodium channel activity; WW domain binding

Biological Process: multicellular organismal water homeostasis; regulation of blood pressure; regulation of body fluid levels; sodium ion homeostasis; sodium ion transport

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