Full Product Name
2AAA Polyclonal Antibody
Product Synonym Names
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PPP2R1A
Product Gene Name
anti-2AAA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P30153
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 500-580
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-2AAA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-2AAA antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-2AAA antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for 2AAA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055040.2
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NCBI GenBank Nucleotide #
NM_014225.5
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UniProt Primary Accession #
P30153
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UniProt Secondary Accession #
Q13773; Q6ICQ3; Q96DH3[Other Products]
UniProt Related Accession #
P30153[Other Products]
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
NCBI Official Synonym Full Names
protein phosphatase 2 scaffold subunit Aalpha
NCBI Official Symbol
PPP2R1A [Similar Products]
NCBI Official Synonym Symbols
MRD36; PP2AA; PR65A; PP2AAALPHA; PP2A-Aalpha
[Similar Products]
NCBI Protein Information
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
UniProt Synonym Protein Names
Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha
UniProt Gene Name
PPP2R1A [Similar Products]
NCBI Summary for 2AAA
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
UniProt Comments for 2AAA
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).
Research Articles on 2AAA
1. Total PP2A activity and PPP2R1A-associated PP2Ac activity were significantly increased in cells overexpressing PPP2R1A-WT. In addition, overexpression of PPP2R1A-WT increased cell proliferation in vitro and tumor growth in vivo
Precautions
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Disclaimer
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