Product Name
Retinoschisin (RS), Polyclonal Antibody
Full Product Name
Cy3-Linked Polyclonal Antibody to Retinoschisin (RS)
Product Synonym Names
RS1; XLRS1; Retinoschisis X-Linked, Juvenile 1; X-linked juvenile retinoschisis protein
Product Gene Name
anti-RS antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Retinoschisin (MBS2027938)
Cy3 Conjugated Antibody: Retinoschisin (RS) (MBS2081867)
Matching Pairs
Cy3 Conjugated Antibody: Retinoschisin (RS) (MBS2081867)
Immunogen: Retinoschisin (MBS2031049)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15537
Concentration
200ug/ml (lot specific)
Immunogen
RS (Ser24~Ala224)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2027938
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-RS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RS antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for RS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000321.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000330.3
[Other Products]
UniProt Primary Accession #
O15537
[Other Products]
UniProt Secondary Accession #
Q0QD39[Other Products]
UniProt Related Accession #
O15537[Other Products]
Molecular Weight
25,592 Da
NCBI Official Full Name
retinoschisin
NCBI Official Synonym Full Names
retinoschisin 1
NCBI Official Symbol
RS1 [Similar Products]
NCBI Official Synonym Symbols
RS; XLRS1
[Similar Products]
NCBI Protein Information
retinoschisin
UniProt Protein Name
Retinoschisin
UniProt Synonym Protein Names
X-linked juvenile retinoschisis protein
UniProt Gene Name
RS1 [Similar Products]
UniProt Synonym Gene Names
XLRS1 [Similar Products]
NCBI Summary for RS
This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
UniProt Comments for RS
RS1: a highly conserved extracellular protein essential for proper retinal structure. Must interact with L-type voltage-gated calcium channels (L-VGCCs) correctly so that the photoreceptor cells in the eye can function properly. Genetic mutations in RS1 cause X-linked retinoschisis (XLRS) and early onset of macular degeneration. Interacts with the L-VGCCa1D subunit, regulating its activity. The expression and secretion of retinoschisin are modulated by circadian rhythms, peaking at night and diminishing during the day.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp22.13
Cellular Component: extracellular space
Biological Process: multicellular organismal development
Disease: Retinoschisis 1, X-linked, Juvenile
Research Articles on RS
1. A novel RS1 (97delT) mutation was identified in a Taiwanese family with X-linked retinoschisis (XLRS). This finding expands the RS1 mutation spectrum and may help to further understand the molecular pathogenesis of XLRS.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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