Product Name
ALOX12, Polyclonal Antibody
Full Product Name
ALOX12, CT (Platelet-type Lipoxygenase 12, Arachidonate 12-lipoxygenase, 12S-type, 12S-lipoxygenase, 12S-LOX, LOG12)
Product Synonym Names
Anti -ALOX12, CT (Platelet-type Lipoxygenase 12, Arachidonate 12-lipoxygenase, 12S-type, 12S-lipoxygenase, 12S-LOX, LOG12)
Product Gene Name
anti-ALOX12 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (6899384..6914055). Location: 17p13.1
3D Structure
ModBase 3D Structure for P18054
Specificity
Recognizes human ALOX12.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the C-terminal region of human ALOX12 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ALOX12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALOX12 antibody
Oxygenase and 14,15-leukotriene A4 synthase activity.
Product Categories/Family for anti-ALOX12 antibody
Antibodies; Abs to Leukotrienes
Applications Tested/Suitable for anti-ALOX12 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ALOX12 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
NCBI/Uniprot data below describe general gene information for ALOX12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000688.2
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NCBI GenBank Nucleotide #
NM_000697.2
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UniProt Primary Accession #
P18054
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UniProt Secondary Accession #
O95569; Q6ISF8; Q9UQM4[Other Products]
UniProt Related Accession #
P18054; Q16120[Other Products]
Molecular Weight
75,694 Da[Similar Products]
NCBI Official Full Name
arachidonate 12-lipoxygenase, 12S-type
NCBI Official Synonym Full Names
arachidonate 12-lipoxygenase
NCBI Official Symbol
ALOX12 [Similar Products]
NCBI Official Synonym Symbols
LOG12; 12-LOX; 12S-LOX
[Similar Products]
NCBI Protein Information
arachidonate 12-lipoxygenase, 12S-type; platelet 12-LOX; 12S-lipoxygenase; OTTHUMP00000128281; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12
UniProt Protein Name
Arachidonate 12-lipoxygenase, 12S-type
UniProt Synonym Protein Names
Platelet-type lipoxygenase 12
Protein Family
Arachidonate 12-lipoxygenase
UniProt Gene Name
ALOX12 [Similar Products]
UniProt Synonym Gene Names
LOG12 [Similar Products]
UniProt Entry Name
LOX12_HUMAN
UniProt Comments for ALOX12
ALOX12: Oxygenase and 14,15-leukotriene A4 synthase activity. Belongs to the lipoxygenase family.
Protein type: Apoptosis; Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.13.11.31
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; cytoplasm; cytosol; sarcolemma
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; hepoxilin A3 synthase activity; protein binding; arachidonate 12-lipoxygenase activity; lipoxygenase activity; hepoxilin-epoxide hydrolase activity; iron ion binding
Biological Process: positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; linoleic acid metabolic process; positive regulation of caspase activity; positive regulation of vasodilation; positive regulation of cell growth; positive regulation of angiogenesis; positive regulation of endothelial cell differentiation; positive regulation of mitochondrial depolarization; lipoxygenase pathway; positive regulation of cell proliferation; arachidonic acid metabolic process; fatty acid oxidation; hepoxilin biosynthetic process; cell motility; hepoxilin metabolic process; superoxide release; aging; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on ALOX12
1. the rs2073438 polymorphism of ALOX12 contributes to the variation of obesity phenotypes in young Chinese men
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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