Product Name
ADAMTS10, Blocking Peptide
Full Product Name
ADAMTS10 Blocking Peptide
Product Synonym Names
A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM-TS 10; ADAM-TS10; ADAMTS-10
Product Gene Name
ADAMTS10 blocking peptide
[Similar Products]
ADAMTS10 peptide (MBS8230691) is used for blocking the activity of ADAMTS10 antibody (MBS8228577)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H324
Species Reactivity
Human, Mouse, Rat, Monkey, Porcine
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ADAMTS10 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ADAMTS10 blocking peptide
The peptide is used to block Anti-ADAMTS10 Antibody reactivity.
Applications Tested/Suitable for ADAMTS10 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for ADAMTS10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269281.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001282352.1
[Other Products]
UniProt Primary Accession #
Q9H324
[Other Products]
UniProt Secondary Accession #
M0QZE4[Other Products]
UniProt Related Accession #
Q9H324[Other Products]
Molecular Weight
62,530 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 2
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NCBI Official Symbol
ADAMTS10 [Similar Products]
NCBI Official Synonym Symbols
WMS; WMS1; ADAM-TS10; ADAMTS-10
[Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 10
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 10
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
ADAMTS10 [Similar Products]
UniProt Synonym Gene Names
ADAM-TS 10; ADAM-TS10; ADAMTS-10 [Similar Products]
UniProt Entry Name
ATS10_HUMAN
NCBI Summary for ADAMTS10
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS10
ADAMTS10: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
Protein type: Secreted, signal peptide; Protease; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular matrix; microfibril
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: proteolysis
Disease: Weill-marchesani Syndrome 1
Research Articles on ADAMTS10
1. These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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