Full Product Name
Mouse Monoclonal Antibody to ITGB4
Product Synonym Names
CD104
Product Gene Name
anti-ITGB4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P16144
Other Notes
Small volumes of anti-ITGB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ITGB4 antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-ITGB4 antibody
Western blot using Recombinant protein
Western blot using Cell lysate
NCBI/Uniprot data below describe general gene information for ITGB4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001308052.1
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NCBI GenBank Nucleotide #
NM_001321123.1
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UniProt Primary Accession #
P16144
[Other Products]
UniProt Secondary Accession #
O14690; O14691; O15339; O15340; O15341; Q0VF97; Q9UIQ4; A0AVL6[Other Products]
UniProt Related Accession #
P16144[Other Products]
NCBI Official Full Name
integrin beta-4 isoform 3
NCBI Official Synonym Full Names
integrin subunit beta 4
NCBI Official Symbol
ITGB4 [Similar Products]
NCBI Official Synonym Symbols
CD104; GP150
[Similar Products]
NCBI Protein Information
integrin beta-4
UniProt Protein Name
Integrin beta-4
UniProt Synonym Protein Names
GP150; CD_antigen: CD104
UniProt Gene Name
ITGB4 [Similar Products]
NCBI Summary for ITGB4
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the
biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGB4
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Research Articles on ITGB4
1. These findings suggest that the integrin beta4-FAK/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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