Full Product Name
Rabbit MED13L Antibody
Product Gene Name
anti-MED13L antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (116396381..116714991, complement). Location: 12q24.21
3D Structure
ModBase 3D Structure for Q71F56
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-MED13L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MED13L antibody
Immunohistochemistry (IHC), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MED13L. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056150.1
[Other Products]
NCBI GenBank Nucleotide #
NM_015335.4
[Other Products]
UniProt Primary Accession #
Q71F56
[Other Products]
UniProt Secondary Accession #
Q68DN4; Q9H8C0; Q9NSY9; Q9UFD8; Q9UPX5; A1L469[Other Products]
UniProt Related Accession #
Q71F56[Other Products]
Molecular Weight
242,602 Da
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 13-like
NCBI Official Synonym Full Names
mediator complex subunit 13-like
NCBI Official Symbol
MED13L [Similar Products]
NCBI Official Synonym Symbols
THRAP2; TRAP240L; PROSIT240
[Similar Products]
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 13-like; thyroid hormone receptor-associated protein 2; thyroid hormone receptor-associated protein complex 240 kDa component-like
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 13-like
UniProt Synonym Protein Names
Mediator complex subunit 13-like; Thyroid hormone receptor-associated protein 2; Thyroid hormone receptor-associated protein complex 240 kDa component-like
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
MED13L [Similar Products]
UniProt Synonym Gene Names
KIAA1025; PROSIT240; THRAP2; TRAP240L [Similar Products]
UniProt Entry Name
MD13L_HUMAN
NCBI Summary for MED13L
The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
UniProt Comments for MED13L
THRAP2: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Defects in MED13L are a cause of transposition of the great arteries dextro-looped type 1 (DTGA1). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients often have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the circulations in order to support life minimally, but surgical intervention is always required. A chromosomal aberration involving MED13L is found in a patient with transposition of the great arteries, dextro- looped and mental retardation. Translocation t(12;17)(q24.1;q21). Belongs to the Mediator complex subunit 13 family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q24.21
Cellular Component: Srb-mediator complex
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Disease: Transposition Of The Great Arteries, Dextro-looped 1
Research Articles on MED13L
1. We show that the Mediator complex subunit MED13L is required for Rb/E2F control of cell growth, the complete repression of cell cycle target genes, and cell cycle inhibition.
Precautions
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