Full Product Name
EVC Antibody
Product Synonym Names
Ellis-van Creveld syndrome protein; DWF-1; EVC
Product Gene Name
anti-EVC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P57679
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Ellis-van Creveld syndrome protein (493-602AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-EVC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EVC antibody
Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development.
Product Categories/Family for anti-EVC antibody
Applications Tested/Suitable for anti-EVC antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EVC antibody
WB: 1:500-1:5000
IHC: 1:20-1:200
Western Blot (WB) of anti-EVC antibody
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
All lanes: EVC antibody at 2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 112 KDa
Observed band size: 112 KDa
Immunohistochemistry (IHC) of anti-EVC antibody
Immunohistochemistry analysis of human pancreatic cancer using MBS7104105 at dilution of 1:100
Immunohistochemistry (IHC) of anti-EVC antibody
Immunocytochemistry analysis of human liver cancer using MBS7104105 at dilution of 1:100
NCBI/Uniprot data below describe general gene information for EVC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001293019.1
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NCBI GenBank Nucleotide #
NM_001306090.1
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UniProt Primary Accession #
P57679
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UniProt Related Accession #
P57679[Other Products]
Molecular Weight
111,990 Da
NCBI Official Full Name
ellis-van Creveld syndrome protein isoform 2
NCBI Official Synonym Full Names
EvC ciliary complex subunit 1
NCBI Official Symbol
EVC [Similar Products]
NCBI Official Synonym Symbols
EVC1; EVCL; DWF-1
[Similar Products]
NCBI Protein Information
ellis-van Creveld syndrome protein
UniProt Protein Name
Ellis-van Creveld syndrome protein
UniProt Synonym Protein Names
DWF-1
Protein Family
Ellis-van Creveld syndrome protein
UniProt Gene Name
EVC [Similar Products]
NCBI Summary for EVC
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]
UniProt Comments for EVC
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Research Articles on EVC
1. T, which leads to a premature stop codon.">Here, we report on two Mexican families with patients diagnosed with Ellis-van Creveld syndrome. In all cases, molecular analysis by Sanger sequencing identified the same homozygous mutation in exon 12 of EVC, c.1678G>T, which leads to a premature stop codon.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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