Product Synonym Names
TLR5
Product Gene Name
anti-TLR5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60602
Species Reactivity
Human, Mouse, Rat
Purity/Purification
ProA affinity purified
Immunogen
Recombinant Protein
Storage Buffer
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
Preservative
0.13% Sodium Azide.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-TLR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLR5 antibody
Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3
Applications Tested/Suitable for anti-TLR5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for TLR5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003259.2
[Other Products]
NCBI GenBank Nucleotide #
NM_003268.5
[Other Products]
UniProt Primary Accession #
O60602
[Other Products]
UniProt Secondary Accession #
O15456; Q32MI2; Q32MI3; B1AZ05; B3Y633; B9VJ63; D1CS80; D3DTB8[Other Products]
UniProt Related Accession #
O60602[Other Products]
Molecular Weight
97,834 Da
NCBI Official Full Name
toll-like receptor 5
NCBI Official Synonym Full Names
toll like receptor 5
NCBI Official Symbol
TLR5 [Similar Products]
NCBI Official Synonym Symbols
SLE1; TIL3; SLEB1; MELIOS
[Similar Products]
NCBI Protein Information
toll-like receptor 5
UniProt Protein Name
Toll-like receptor 5
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 3
Protein Family
Toll-like receptor
UniProt Gene Name
TLR5 [Similar Products]
UniProt Synonym Gene Names
TIL3 [Similar Products]
NCBI Summary for TLR5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
UniProt Comments for TLR5
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Research Articles on TLR5
1. It was observed that the TLR5 polymorphisms rs5744168, rs2072493, and rs5744174 are less frequent in Indian Tamils, suggesting that the TLR5 gene remains conserved, which may be due to the genetic selection pressure to withstand prevailing endemic infectious diseases. We observed that these polymorphisms also failed to confer significant risk to develop chronic H. pylori infections and its associated clinical phenotypes
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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