Product Name
TLR5, Blocking Peptide
Full Product Name
TLR5 Peptide
Product Synonym Names
TIL3; SLEB1; MELIOS; TIL3; Toll-like receptor 5; toll-like receptor 5
Product Gene Name
TLR5 blocking peptide
[Similar Products]
TLR5 peptide (MBS151998) is used for blocking the activity of TLR5 antibody (MBS151431)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60602
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
15 amino acids near the carboxy terminus of human TLR5.
Preparation and Storage
Store TLR5 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of TLR5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for TLR5 blocking peptide
Blocking (BL)
Application Notes for TLR5 blocking peptide
TLR5 peptide is used for blocking the activity of TLR5 antibody.
NCBI/Uniprot data below describe general gene information for TLR5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003259
[Other Products]
NCBI GenBank Nucleotide #
NM_003268.5
[Other Products]
UniProt Primary Accession #
O60602
[Other Products]
UniProt Secondary Accession #
O15456; Q32MI2; Q32MI3; B1AZ05; B3Y633; B9VJ63; D1CS80; D3DTB8[Other Products]
UniProt Related Accession #
O60602[Other Products]
Molecular Weight
97,834 Da
NCBI Official Full Name
toll-like receptor 5
NCBI Official Synonym Full Names
toll-like receptor 5
NCBI Official Symbol
TLR5 [Similar Products]
NCBI Official Synonym Symbols
SLE1; TIL3; SLEB1; MELIOS
[Similar Products]
NCBI Protein Information
toll-like receptor 5; toll/interleukin-1 receptor-like protein 3; systemic lupus erythematosus susceptibility 1
UniProt Protein Name
Toll-like receptor 5
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 3
Protein Family
Toll-like receptor
UniProt Gene Name
TLR5 [Similar Products]
UniProt Synonym Gene Names
TIL3 [Similar Products]
UniProt Entry Name
TLR5_HUMAN
NCBI Summary for TLR5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
UniProt Comments for TLR5
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q41-q42
Cellular Component: integral to membrane; plasma membrane
Molecular Function: interleukin-1 receptor binding; transmembrane receptor activity
Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; male gonad development; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; inflammatory response; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway
Disease: Legionnaire Disease, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1; Melioidosis, Susceptibility To
Research Articles on TLR5
1. A family was heterozygous for risk variants of the genes encoding NOD2 and TLR5 and homozygous carriers of PTPN2 risk alleles in Crohn disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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