Product Name
TLR5, cDNA Clone
Full Product Name
TLR5 cDNA Clone
Product Gene Name
TLR5 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGGAGACC ACCTGGACCT TCTCCTAGGA GTGGTGCTCA TGGCCGGTCC TGTGTTTGGA ATTCCTTCCT GCTCCTTTGA TGGCCGAATA GCCTTTTATC GTTTCTGCAA CCTCACCCAG GTCCCCCAGG TCCTCAACAC CACTGAGAGG CTCCTGCTGA GCTTCAACTA TATCAGGACA GTCACTGCTT CATCCTTCCC CTTTCTGGAA CAGCTGCAGC TGCTGGAGCT CGGGAGCCAG TATACCCCCT TGACTATTGA CAAGGAGGCC TTCAGAAACC TGCCCAACCT TAGAATCTTG GACCTGGGAA GTAGTAAGAT ATACTTCTTG CATCCAGATG CTTTTCAGGG ACTGTTCCAT CTGTTTGAAC TTAGACTGTA TTTCTGTGGT CTCTCTGATG CTGTATTGAA AGATGGTTAT TTCAGAAATT TAAAGGCTTT AACTCGCTTG GATCTATCCA AAAATCAGAT TCGTAGCCTT TACCTTCATC CTTCATTTGG GAAGTTGAAT TCCTTAAAGT CCATAGATTT TTCCTCCAAC CAAATATTCC TTGTATGTGA ACATGAGCTC GAGCCCCTAC AAGGGAAAAC GCTCTCCTTT TTTAGCCTCG CAGCTAATAG CTTGTATAGC AGAGTCTCAG TGGACTGGGG AAAATGTATG AACCCATTCA GAAACATGGT GCTGGAGATA CTAGATGTTT CTGGAAATGG CTGGACAGTG GACATCACAG GAAACTTTAG CAATGCCATC AGCAAAAGCC AGGCCTTCTC TTTGATTCTT GCCCACCACA TCATGGGTGC CGGGTTTGGC TTCCATAACA TCAAAGATCC TGACCAGAAC ACATTTGCTG GCCTGGCCAG AAGTTCAGTG AGACACCTGG ATCTTTCACA TGGGTTTGTC TTCTCCCTGA ACTCACGAGT CTTTGAGACA CTCAAGGATT TGAAGGTTCT GAACCTTGCC TACAACAAGA TAAATAAGAT TGCAGATGAA GCATTTTACG GACTTGACAA CCTCCAAGTT CTCAATTTGT CATATAACCT TCTGGGGGAA CTTTACAGTT CGAATTTCTA TGGACTACCT AAGGTAGCCT ACATTGATTT GCAAAAGAAT CACATTGCAA TAATTCAAGA CCAAACATTC AAATTCCTGG AAAAATTACG GACCTTGGAT CTCCGAGACA ATGCTCTTAC AACCATTCAT TTTATTCCAA GCATACCCGA TATCTTCTTG AGTGGCAATA AACTAGTGAC TTTGCCAAAG ATCAACCTTA CAGCGAACCT CATCCACTTA TCAGAAAACA GGCTAGAAAA TCTAGATATT CTCTACTTTC TCCTACGGGT ACCTCATCTC CAGATTCTCA TTTTAAATCA AAATCGCTTC TCCTCCTGTA GTGGAGATCA AACCCCTTCA GAGAATCCCA GCTTAGAACA GCTTTTCCTT GGAGAAAATA TGTTGCAACT TGCCTGGGAA ACTGAGCTCT GTTGGGATGT TTTTGAGGGA CTTTCTCATC TTCAAGTTCT GTATTTGAAT CATAACTATC TTAATTCCCT TCCACCAGGA GTATTTAGCC ATCTGACTGC ATTAAGGGGA CTAAGCCTCA ACTCCAACAG GCTGACAGTT CTTTCTCACA ATGATTTACC TGCTAATTTA GAGATCCTGG ACATATCCAG GAACCAGCTC CTAGCTCCTA ATCCTGATGT ATTTGTATCA CTTAGTGTCT TGGATATAAC TCATAACAAG TTCATTTGTG AATGTGAACT TAGCACTTTT ATCAATTGGC TTAATCACAC CAATGTCACT ATAGCTGGGC CTCCTGCAGA CATATATTGT GTGTACCCTG ACTCGTTCTC TGGGGTTTCC CTCTTCTCTC TTTCCACGGA AGGTTGTGAT GAAGAGGAAG TCTTAAAGTC CCTAAAGTTC TCCCTTTTCA TTGTATGCAC TGTCACTCTG ACTCTGTTCC TCATGACCAT CCTCACAGTC ACAAAGTTCC GGGGCTTCTG TTTTATCTGT TATAAGACAG CCCAGAGACT GGTGTTCAAG GACCATCCCC AGGGCACAGA ACCTGATATG TACAAATATG ATGCCTATTT GTGCTTCAGC AGCAAAGACT TCACATGGGT GCAGAATGCT TTGCTCAAAC ACCTGGACAC TCAATACAGT GACCAAAACA GATTCAACCT GTGCTTTGAA GAAAGAGACT TTGTCCCAGG AGAAAACCGC ATTGCCAATA TCCAGGATGC CATCTGGAAC AGTAGAAAGA TCGTTTGTCT TGTGAGCAGA CACTTCCTTA GAGATGGCTG GTGCCTTGAA GCCTTCAGTT ATGCCCAGGG CAGGTGCTTA TCTGACCTTA ACAGTGCTCT CATCATGGTG GTGGTTGGGT CCTTGTCCCA GTACCAGTTG ATGAAACATC AATCCATCAG AGGCTTTGTA CAGAAACAGC AGTATTTGAG GTGGCCTGAG GATCTCCAGG ATGTTGGCTG GTTTCTTCAT AAACTCTCTC AACAGATACT AAAGAAAGAA AAAGAAAAGA AGAAAGACAA TAACATTCCG TTGCAAACTG TAGCAACCAT CTCCTAA
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TLR5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TLR5. It may not necessarily be applicable to this product.
NCBI Accession #
BC109119
[Other Products]
UniProt Secondary Accession #
O15456; Q32MI2; Q32MI3; B1AZ05; B3Y633; B9VJ63; D1CS80; D3DTB8[Other Products]
UniProt Related Accession #
O60602[Other Products]
Molecular Weight
97,834 Da
NCBI Official Full Name
Homo sapiens toll-like receptor 5, mRNA
NCBI Official Synonym Full Names
toll like receptor 5
NCBI Official Symbol
TLR5 [Similar Products]
NCBI Official Synonym Symbols
SLE1; TIL3; SLEB1; MELIOS
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NCBI Protein Information
toll-like receptor 5
UniProt Protein Name
Toll-like receptor 5
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 3
Protein Family
Toll-like receptor
UniProt Gene Name
TLR5 [Similar Products]
UniProt Synonym Gene Names
TIL3 [Similar Products]
UniProt Entry Name
TLR5_HUMAN
NCBI Summary for TLR5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
UniProt Comments for TLR5
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q41-q42
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: interleukin-1 receptor binding; receptor activity
Biological Process: defense response to Gram-negative bacterium; inflammatory response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway
Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1
Research Articles on TLR5
1. TLR-5 was more abundant in OSCC than in CSCC samples.
Precautions
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Disclaimer
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