Full Product Name
LMNB2 Rabbit Polyclonal
Product Gene Name
anti-LMNB2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-LMNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LMNB2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for LMNB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_116126.3
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NCBI GenBank Nucleotide #
NM_032737.3
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UniProt Secondary Accession #
O75292; Q14734; Q96DF6[Other Products]
UniProt Related Accession #
Q03252[Other Products]
Molecular Weight
69,948 Da
NCBI Official Full Name
lamin-B2
NCBI Official Synonym Full Names
lamin B2
NCBI Official Symbol
LMNB2 [Similar Products]
NCBI Official Synonym Symbols
EPM9; LMN2; LAMB2
[Similar Products]
NCBI Protein Information
lamin-B2
UniProt Protein Name
Lamin-B2
UniProt Gene Name
LMNB2 [Similar Products]
UniProt Synonym Gene Names
LMN2 [Similar Products]
UniProt Entry Name
LMNB2_HUMAN
NCBI Summary for LMNB2
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
UniProt Comments for LMNB2
Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: lamin filament; nuclear inner membrane
Molecular Function: structural molecule activity
Disease: Epilepsy, Progressive Myoclonic, 9; Lipodystrophy, Partial, Acquired, Susceptibility To
Research Articles on LMNB2
1. Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Precautions
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Disclaimer
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