Integrin beta-3, Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Cell Free Expression

Liquid containing glycerol

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Itgb3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a recombinant transmembrane protein expressed in a cell-free expression system.

Transmembrane Protein

86,738 Da

integrin beta 3

integrin beta-3

Integrin beta-3

GPIIIa  [Similar Products]

ITB3_MOUSE

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Cellular Component: apical plasma membrane; cell surface; external side of plasma membrane; filopodium membrane; focal adhesion; integrin complex; melanosome; membrane; microvillus membrane; nucleus; plasma membrane; receptor complex

Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; integrin binding; peptide binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding

Biological Process: activation of protein kinase activity; cell adhesion; cell growth; cell migration; cell projection morphogenesis; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular calcium ion homeostasis; entry of virus into host cell; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of bone resorption; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of leukocyte migration; positive regulation of MAPKKK cascade; positive regulation of osteoblast proliferation; positive regulation of osteoclast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell migration; regulation of G-protein coupled receptor protein signaling pathway; regulation of release of sequestered calcium ion into cytosol; smooth muscle cell migration

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